Michael R. Barnes

The paper analyzes peptide-level evidence from proteomics datasets and finds a depletion of basic peptides in detected evidence compared to theoretical tryptic peptides.

Varformer prioritizes drug targets and variants by integrating variant and gene features using a transformer model, achieving high precision across diverse benchmarks.

The paper develops a molecular interaction map of Sjogren's disease using transcriptomic data and literature, integrating pathway analysis and experimental data for therapeutic insights.

In db/db mice, six weeks of AZD1656 improved diastolic function, cardiac metabolism and infarct size, with increased Treg infiltration and less fibrosis, without glycaemic change.

This study investigates the role of XOR-derived nitric oxide in cardiovascular health using Xdh-deleted mice, finding that reduced nitrite reductase activity leads to endothelial dysfunction and hypertension.

GEOexplorer is an R/Bioconductor package that enables interactive and reproducible microarray gene expression analysis with visualisation tools.

The paper shows that RNA prevents protein aggregation in cell lysates, and that RNA degradation leads to protein aggregation, with specific RNA structures being effective in maintaining protein solubility.

M3C improves consensus clustering by simulating null distributions to reduce bias and false positives in determining the number of clusters.

Spectrum improves clustering speed and performance for single and multi-omic data by using a density-aware kernel and tensor product graph integration.

This study identifies 210 genetic loci associated with the PR interval through multi-ancestry GWAS, highlighting their role in cardiac conduction and cardiovascular disease.

This study identifies 6 new blood pressure loci and 48 genes involved in BP regulation using GWAS and gene expression data from blood and kidney tissues.

The paper uses GWAS summary statistics to identify enrichment of heritability in immune system annotations for Alzheimer’s and Parkinson’s diseases.