ER Stress-Induced beta-Cell Apoptosis is Linked to Novel Select Lipid Signaling at the Transcriptional Level: Implications in T1D Development
XIAOYONG Y. LEI, Anil Kumar Challa, Susan E. Nozell, Tomader Ali, Daniel Stephenson, Andrew Nafzinger, Chad S. Hunter, Adam R. Wende, Ernesto Satoshi Nakayasu, Ying Gai, Charles Edward Chalfant, Sasanka Ramanadham
This study identifies a novel lipid signaling pathway involving iPLA2β that links ER stress to β-cell apoptosis in T1D, revealing transcriptional regulation by iDLs and potential therapeutic targets.
bioRxiv · Mar 6, 2026 · PreprintCell Biology