Author

Sasanka Ramanadham

University of Alabama at BirminghamORCID 0000-0002-1664-0657Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anil Kumar ChallaiD· 2 shared Aaliya Ahamed· 1 shared Adam R. WendeiD· 1 shared Andrew Nafzinger· 1 shared Arumugam Gurusamy· 1 shared Chad S. HunteriD· 1 shared Charles Edward ChalfantiD· 1 shared Daniel StephensoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Anil Kumar ChallaORCID

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2 papers

Recent·Most cited

An integrated workflow for dual-guide CRISPR-Cas9 targeting and amplicon-based genotyping of Pla2g6 in primary mouse bone marrow-derived macrophages

Anil Kumar Challa, Sasanka Ramanadham, Rithvikha Nair, Arumugam Gurusamy, Jonathan R Folmar, Thi Yen Ly Huynh, Aaliya Ahamed, Sriharsha Chowdarapu

This paper describes a workflow for dual-guide CRISPR-Cas9 editing of Pla2g6 in mouse BMDMs, showing high editing efficiency and specific deletion patterns.

bioRxiv · Nov 4, 2026 · PreprintMolecular Biology

ER Stress-Induced beta-Cell Apoptosis is Linked to Novel Select Lipid Signaling at the Transcriptional Level: Implications in T1D Development

XIAOYONG Y. LEI, Anil Kumar Challa, Susan E. Nozell, Tomader Ali, Daniel Stephenson, Andrew Nafzinger, Chad S. Hunter, Adam R. Wende, Ernesto Satoshi Nakayasu, Ying Gai, Charles Edward Chalfant, Sasanka Ramanadham

This study identifies a novel lipid signaling pathway involving iPLA2β that links ER stress to β-cell apoptosis in T1D, revealing transcriptional regulation by iDLs and potential therapeutic targets.

bioRxiv · Mar 6, 2026 · PreprintCell Biology