Biological Aging of CNS-Resident Cells Alters the Clinical Course and Immunopathology of Autoimmune Demyelinating Disease
Jeffrey Atkinson, Andrew David Jerome, Andrew Sas, Ashley N Munie, Cankun Wang, Anjun Ma, William David Arnold, Benjamin M. Segal
This study shows that aging of CNS-resident cells worsens EAE severity and reduces remission in mice, suggesting microglial activation and aging properties as therapeutic targets for progressive MS.
JCI Insight · May 5, 2022Peer-reviewedNeuroscience