NeuroscienceJCI InsightPeer-reviewed
Biological Aging of CNS-Resident Cells Alters the Clinical Course and Immunopathology of Autoimmune Demyelinating Disease
Jeffrey Atkinson, Andrew David Jerome, Andrew Sas…·Benjamin M. Segal
This study shows that aging of CNS-resident cells worsens EAE severity and reduces remission in mice, suggesting microglial activation and aging properties as therapeutic targets for progressive MS.
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