William David Arnold

This study shows that short-term hindlimb immobilization in rats causes neuromuscular junction (NMJ) transmission defects, leading to muscle weakness disproportionate to atrophy.

This study creates and characterizes Nefl E397K mouse models of CMT2E, showing early axonal neuropathy and electrophysiological abnormalities.

This study shows that the MuSK-BMP pathway regulates Nav1.4 localization and muscle excitability at the neuromuscular junction, with implications for congenital myasthenic syndromes and aging.

This study shows that aging of CNS-resident cells worsens EAE severity and reduces remission in mice, suggesting microglial activation and aging properties as therapeutic targets for progressive MS.