Author

Andy Burnim

National Institutes of Health

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Evolutionary Biology· 1

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Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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Alexander Edward LipkaiD· 1 shared Holger SondermanniD· 1 shared Keith Dufault‐ThompsoniD· 1 shared Sofia MortenseniD· 1 shared Xiaofang JiangiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperEvolutionary Biology

Alexander Edward LipkaORCID

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1 paper

Recent·Most cited

Ancestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases

Sofia Mortensen, Andy Burnim, Keith Dufault‐Thompson, Alexander Edward Lipka, Xiaofang Jiang, Holger Sondermann

This study reconstructs ancestral bacterial DEDDy dinucleases to trace the evolution of substrate specificity and oligomerization from a dimeric ancestor with intermediate preferences.

Science Advances · Aug 12, 2026Peer-reviewedEvolutionary Biology