Author

Sofia Mortensen

Deutsches Elektronen-Synchrotron DESYORCID 0000-0003-1631-6651Unclaimed ORCID profile · follow to get notified of new preprints

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Evolutionary Biology· 1

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Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexander Edward LipkaiD· 1 shared Andy Burnim· 1 shared Holger SondermanniD· 1 shared Keith Dufault‐ThompsoniD· 1 shared Xiaofang JiangiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperEvolutionary Biology

Alexander Edward LipkaORCID

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1 paper

Recent·Most cited

Evolutionary BiologyScience AdvancesPeer-reviewedAug 12, 2026

Ancestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases

Sofia Mortensen, Andy Burnim, Keith Dufault‐Thompson…·Holger Sondermann

This study reconstructs ancestral bacterial DEDDy dinucleases to trace the evolution of substrate specificity and oligomerization from a dimeric ancestor with intermediate preferences.

DOI 10.1126/sciadv.aef1581

bacteria (other)protein structure

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