Holger Sondermann

This study reconstructs ancestral bacterial DEDDy dinucleases to trace the evolution of substrate specificity and oligomerization from a dimeric ancestor with intermediate preferences.

The paper identifies negative hysteresis as a robust phenomenon in Pseudomonas aeruginosa that enhances antibiotic efficacy through increased aminoglycoside uptake after beta-lactam treatment.

This study identifies three secreted retropepsin-like proteases in Pseudomonas aeruginosa essential for stress tolerance and biofilm formation, with implications for therapeutic strategies against bacterial infections.

This study shows that HOPS/CORVET complexes are essential for malaria parasite endocytosis and invasion organelle function, with distinct roles in different developmental stages.

This study reconstitutes a biofilm adhesin system from Desulfovibrio vulgaris in Pseudomonas fluorescens, showing that DvhA's N-terminal fragment is regulated by DvhG/DvhD and c-di-GMP levels.