Microglial metabolic reprogramming drives cognitive decline in heart failure with preserved ejection fraction
Swapna Patil, Connor W. Lantz, Angela Marinovic, Ripon Sarkar, Bo Ryung Lee, Matthew DeBerge
This study shows that microglial metabolic reprogramming in HFpEF drives neuroinflammation and cognitive decline, with HIF-1 signaling as a key mediator.
bioRxiv · Sep 10, 2025 · PreprintImmunology