Complementary Models of Cardiometabolic Stress Reveal Conserved Molecular Programs Driving Cardiac Remodeling
Maaria Saeed, Hyun-Jung Jung, Bo Ryung Lee, Swapna Patil, Ripon Sarkar, Connor W. Lantz, Mi Jeong Heo, Alexandra Serrato, Yu A An, Kang Ho Kim, Matthew DeBerge
The paper identifies conserved molecular responses to cardiometabolic stress across different disease models and finds PAI-1 as a key mediator of cardiac remodeling.
bioRxiv · Aug 31, 2026 · PreprintSystems Biology