Neutrophil NADPH oxidase breaks the inflammatory IL-1beta/IL-17A circuit to enhance pathogen clearance during respiratory virus infections.
Aderonke Sofoluwe, Angelos Petropoulos, Zehra Fatima Ali-Khan, Abhilesh Salil Goomanee, Simon J. Cleary, Annika Warnatsch
This study shows that neutrophil NADPH oxidase 2 generates ROS early in influenza infection, suppressing IL-1β and limiting IL-17A-driven immune responses to enhance antiviral defense.
Nature Communications · Aug 5, 2026Peer-reviewedImmunology