Simon J. Cleary

This study demonstrates that fast green FCF staining enables sensitive and specific 3D imaging of pulmonary fibrosis in mouse and human lung samples using fluorescence microscopy.

The paper identifies emperipolesis as a process where megakaryocytes transfer proteins to neutrophils, enhancing their immune function and migration.

This study shows that neutrophil NADPH oxidase 2 generates ROS early in influenza infection, suppressing IL-1β and limiting IL-17A-driven immune responses to enhance antiviral defense.

This study shows that Syk inhibition reduces hemin-induced thromboinflammation and improves perfusion in the lungs and kidneys of sickle cell mice.

This paper develops a technique for intravital imaging of pulmonary lymphatics in mice, revealing ventilation-dependent and -independent lymph flow and leukocyte migration during inflammation and cancer metastasis.

This study shows that loss of neutrophil Shp1 causes severe lung injury and death in mice, and that activating Shp1 can reduce inflammation and lung damage.

This study shows that IgG hexamerization is critical for triggering acute lung injury and suggests therapeutic strategies targeting hexamer formation.