mRNAfold: Co-optimization of Global Stability, Local Structure, and Codon Choice via Suboptimal Folding
Max Ward, Mary O.G. Richardson, Hainin Lin, Michae Stamm, Kathryn Wright, Angie Kim, Alicia A. Bicknell, Nabeel Ahmed, Adriana K. Jones, J. Wade Davis, Mihir Metkar
mRNAfold improves mRNA design by co-optimizing stability, local structure, and codon choice, showing better in-solution stability and complex effects on protein production.
bioRxiv · Jan 26, 2026 · PreprintBioinformatics