Mihir Metkar

This paper improves mRNA stability prediction by incorporating fine-scale structural metrics into a regression model, achieving better accuracy than existing methods.

This paper develops new RNA folding nearest neighbor parameters for sequences containing 1-methyl-pseudouridine, showing it stabilizes RNA folding and improves tRNA ensemble modeling.

mRNAfold improves mRNA design by co-optimizing stability, local structure, and codon choice, showing better in-solution stability and complex effects on protein production.

The paper uses EJC RIPiT-Seq to quantify pre-translational mRNPs and reveals higher flux through AS-NMD pathways than RNA-Seq captures.

This study develops a method to probe mRNA 3D structures and finds that pre-translational mRNPs form linear rod-like structures without strong end interactions.