Pharmacology & ToxicologybioRxivPreprint
Artificial Brain Extracellular Fluid in Radioligand Binding Assays: Effects on Affinities of Ligands at Serotonin 5-HT7 Receptors
Anh Tuan Huynh, Haifa Kathrin Al‐Ali, Jason V. Wallach, Clinton Ernest Canal
This study compares ligand affinities at 5-HT7 receptors using standard buffer vs. artificial brain extracellular fluid, finding that temperature and buffer composition significantly affect antagonist/inverse agonist affinities but not agonist affinity.
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