In vivo engineered quadrivalent CAR-macrophages break tumor barrier,remodel TME and overcome tumor heterogeneity through antigen spreading
Shaolong Zhang, Hengxing Lu, Hailing Zhang, Xizhong Ding, Qixin Wu, Anhua Lei, Na Kong, Jin Zhang
This study develops in vivo engineered quadrivalent CAR-macrophages that break tumor barriers, remodel the TME, and overcome tumor heterogeneity through antigen spreading, achieving complete tumor regression.
bioRxiv · Nov 6, 2024 · PreprintBioengineering