Jin Zhang

This study shows that loss of C3 and CD14 reduces neuroinflammation in a murine polytrauma model, with differential effects across brain regions.

The paper shows that editing colonic epithelial cells in vivo to enhance efferocytosis reduces intestinal inflammation in mice.

The paper infers metabolic objectives and tradeoffs in single cells during embryogenesis using integrated omics data and a novel framework combining metabolic modeling and machine learning.

This study develops in vivo engineered quadrivalent CAR-macrophages that break tumor barriers, remodel the TME, and overcome tumor heterogeneity through antigen spreading, achieving complete tumor regression.