Mechanistic modeling suggests stroma-targeting antibody-drug conjugates as an alternative to cancer-targeting in cases of heterogeneous target expression
N. Ezgi Wood, Anil Cengiz, Ming Gao, Alexander V. Ratushny, Ronny Straube
This paper uses mathematical models to compare cancer-targeting and stroma-targeting ADCs, finding that stroma-targeting may be more effective in cases of heterogeneous antigen expression.
bioRxiv · Jan 31, 2025 · PreprintPharmacology & Toxicology