Pharmacology & ToxicologybioRxivPreprint
Mechanistic modeling suggests stroma-targeting antibody-drug conjugates as an alternative to cancer-targeting in cases of heterogeneous target expression
N. Ezgi Wood, Anil Cengiz, Ming Gao…·Ronny Straube
This paper uses mathematical models to compare cancer-targeting and stroma-targeting ADCs, finding that stroma-targeting may be more effective in cases of heterogeneous antigen expression.
DOI 10.1101/2025.01.31.635847