N. Ezgi Wood

Synergistic and antagonistic drug interactions are prevalent but not conserved across acute myeloid leukemia cell lines

This study investigates drug-drug interactions in AML cell lines, finding widespread but non-conserved synergistic and antagonistic effects across different cell lines.

Mechanistic modeling suggests stroma-targeting antibody-drug conjugates as an alternative to cancer-targeting in cases of heterogeneous target expression

This paper uses mathematical models to compare cancer-targeting and stroma-targeting ADCs, finding that stroma-targeting may be more effective in cases of heterogeneous antigen expression.