Phase separation as a concentrating mechanism of protein/peptide hormones for the secretory granule storage
Semanti Mukherjee, Debkanya Sengupta, Prasad Sulkshane, Anindya Modak, Supriya Singh, Shouvik Manna, Ajoy Paul, Ranjit Shaw, Jyoti Devi, Shalaka Arun Masurkar, Riya Bera, Samir Kumar Maji
This study shows that protein/peptide hormones undergo phase separation at the TGN, forming amyloid-like structures that enable efficient storage and regulated release in secretory granules.
bioRxiv · Dec 8, 2025 · PreprintBiochemistry