Loop extrusion dynamics and cooperative activation independently regulate enhancer-driven transcription
Elias T. Friman, Hannah J Juellig, Grace Alston, Luciana I. Gómez Acuña, Shelagh Boyle, Milena Flankova, Alba Muñoz Grande, Giovanna Weykopf, Anita Mann, Iain Williamson, Laura A. Lettice, Wendy A. Bickmore
The paper shows that loop extrusion and enhancer cooperativity independently affect enhancer-driven transcription through synthetic gene activation experiments.
bioRxiv · May 7, 2026 · PreprintMolecular Biology