Iain Williamson

The paper shows that loop extrusion and enhancer cooperativity independently affect enhancer-driven transcription through synthetic gene activation experiments.

The paper shows that some Shh enhancers can activate transcription of both Shh and Mnx1 genes across a TAD boundary, supporting a cohesin-dependent hub model for enhancer function.

The paper shows that disrupting PRC1 condensates with 1,6-hexandiol reversibly disrupts polycomb chromatin domains and loops in mouse embryonic stem cells.

This study shows cohesin, but not CTCF, is required for activation of genes by distant enhancers, while close enhancers can function without cohesin.

This study investigates the role of PRC1 in shaping 3D nuclear organization in mESCs, showing that PRC1-mediated interactions are independent of CTCF and can occur at a megabase scale.

The paper shows that Shh expression remains robust to TAD perturbations during development, except when enhancers are deleted.

The paper identifies PARP1-mediated chromatin unfolding as a mechanism for long-range enhancer activation at the Shh locus in neural progenitor cells.