Author

Luciana I. Gómez Acuña

Institute of Genetics and CancerORCID 0000-0002-0696-1895Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:Hi-C· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Elias T. FrimaniD· 2 shared Shelagh Boyle· 2 shared Wendy A. BickmoreiD· 2 shared Alba Muñoz Grande· 1 shared Anita Mann· 1 shared Giovanna WeykopfiD· 1 shared Grace AlstoniD· 1 shared Hannah J JuelligiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Elias T. FrimanORCID

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2 papers

Recent·Most cited

Loop extrusion dynamics and cooperative activation independently regulate enhancer-driven transcription

Elias T. Friman, Hannah J Juellig, Grace Alston, Luciana I. Gómez Acuña, Shelagh Boyle, Milena Flankova, Alba Muñoz Grande, Giovanna Weykopf, Anita Mann, Iain Williamson, Laura A. Lettice, Wendy A. Bickmore

The paper shows that loop extrusion and enhancer cooperativity independently affect enhancer-driven transcription through synthetic gene activation experiments.

bioRxiv · May 7, 2026 · PreprintMolecular Biology

Transcription decouples estrogen-dependent changes in enhancer-promoter contact frequencies and spatial proximity

Luciana I. Gómez Acuña, Ilya M. Flyamer, Shelagh Boyle, Elias T. Friman, Wendy A. Bickmore

The paper investigates how estrogen receptor activation affects enhancer-promoter contact frequencies and spatial proximity, finding they change independently during gene activation.

PLoS Genetics · May 23, 2024Peer-reviewedGenomics