HIV-1 Unspliced RNA Expression Induces Innate Immune Activation in Macrophages
Hisashi Akiyama, Caitlin M. Miller, Chelsea R. Ettinger, Anna C. Belkina, Jennifer Snyder-Cappione, Suryaram Gummuluru
This study shows HIV-1 unspliced RNA induces innate immune activation in macrophages through Rev-CRM1-dependent nuclear export and sensing, leading to IFN-I-dependent inflammation.
bioRxiv · Aug 10, 2017 · PreprintMicrobiology