Suryaram Gummuluru

Intragenic Transcription from Defective HIV Proviruses Triggers Interferon Responses in Myeloid Cells

This study shows defective HIV proviruses trigger type I interferon responses in myeloid cells through MDA5-dependent pathways, contributing to chronic inflammation in people with HIV.

Bloom syndrome helicase is required for efficient HIV-1 reverse transcription in macrophages

This study identifies Bloom syndrome helicase (BLM) as a host factor that promotes HIV-1 reverse transcription and integration in macrophages through CRISPR screening and functional assays.

Evasion of CARD8 Activation During HIV-1 Assembly

This study shows HIV-1 Gag suppresses CARD8 activation by controlling protease timing, and host-adaptive mutations in Gag help evade CARD8-mediated cell death.

Expression of Intron-containing HIV-1 RNA Induces NLRP1 Inflammasome Activation in Myeloid Cells

This study shows that HIV-1 intron-containing RNA induces NLRP1 inflammasome activation and IL-1β secretion in myeloid cells through a RLR- and endosomal TLR-independent mechanism.

5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5

This study shows that MDA5 senses HIV-1 unspliced RNA based on 5' cap structure and nuclear export pathway, revealing how the virus evades innate immunity.

Macrophage-intrinsic MDA5-IRF5 axis drives HIV-1 icRNA-induced inflammatory responses

This study identifies the MDA5-IRF5 axis as critical for HIV-1 icRNA-induced inflammatory responses in macrophages, with IRF5 mediating enhanced IP-10 expression in older individuals.

HIV-1 Unspliced RNA Expression Induces Innate Immune Activation in Macrophages

This study shows HIV-1 unspliced RNA induces innate immune activation in macrophages through Rev-CRM1-dependent nuclear export and sensing, leading to IFN-I-dependent inflammation.