Hisashi Akiyama

This study shows HIV-1 Gag suppresses CARD8 activation by controlling protease timing, and host-adaptive mutations in Gag help evade CARD8-mediated cell death.

This paper introduces a proteogenomic framework combining genetic perturbations and proteomics to map phospho-signaling pathways in primary human T cells, validated with inflammatory stimuli.

This study shows that HIV-1 intron-containing RNA induces NLRP1 inflammasome activation and IL-1β secretion in myeloid cells through a RLR- and endosomal TLR-independent mechanism.

This study shows that MDA5 senses HIV-1 unspliced RNA based on 5' cap structure and nuclear export pathway, revealing how the virus evades innate immunity.

This study identifies the MDA5-IRF5 axis as critical for HIV-1 icRNA-induced inflammatory responses in macrophages, with IRF5 mediating enhanced IP-10 expression in older individuals.

This study shows HIV-1 unspliced RNA induces innate immune activation in macrophages through Rev-CRM1-dependent nuclear export and sensing, leading to IFN-I-dependent inflammation.