Inverted topographies in sequential fitness landscapes enable evolutionary control
Peng Chen, Nikhil P. Krishnan, Anna E. Stacy, Davis T. Weaver, Rowan J Barker-Clarke, Michael Hinczewski, Jeff Maltas, Jacob G. Scott
This paper introduces a new metric, edge flip fraction, to compare fitness landscapes and shows it predicts evolutionary trajectories and drug sequence optimality.
bioRxiv · Dec 29, 2024 · PreprintEvolutionary Biology