Jeff Maltas

The paper shows that targeted therapy resistance in cancer selects for cells with higher phenotypic plasticity, which enhances their ability to adapt to other stressors and promotes metastasis.

The paper develops a multiplexed mouse model to study TBX2 subfamily and Egr1 roles in Ras-driven lung cancer, finding Egr1 loss significantly increases tumor size and suggests immune dysregulation.

This paper introduces a new metric, edge flip fraction, to compare fitness landscapes and shows it predicts evolutionary trajectories and drug sequence optimality.