Rowan J Barker-Clarke

The paper shows that targeted therapy resistance in cancer selects for cells with higher phenotypic plasticity, which enhances their ability to adapt to other stressors and promotes metastasis.

This paper introduces a new metric, edge flip fraction, to compare fitness landscapes and shows it predicts evolutionary trajectories and drug sequence optimality.

The paper studies how asymmetric interactions affect mutant survival during population range expansions using simulations and a mathematical model.

This study shows that cell-cell fusion in NSCLC leads to increased chemoresistance and tumor aggressiveness by creating hybrid cells with enhanced fitness and genomic heterogeneity.

The paper introduces graph texture features, a novel method for analyzing network structures, and applies it to cancer informatics to classify cell lines by lineage with high accuracy.