Peng Chen

Stochastic Evolutionary Control in Heterogeneous Populations

This paper introduces SHEPHERD, a method combining population genetics and MDPs to design adaptive drug policies that reduce disease fitness in heterogeneous populations, showing effectiveness in synthetic multi-drug landscapes.

Controlling treatment toxicity in ovarian cancer to prime the patient for tumor extinction therapy

This paper develops computational frameworks to design personalized multi-strike therapies for ovarian cancer that reduce toxicity while enhancing tumor extinction.

Inverted topographies in sequential fitness landscapes enable evolutionary control

This paper introduces a new metric, edge flip fraction, to compare fitness landscapes and shows it predicts evolutionary trajectories and drug sequence optimality.