PI3K/AKT signalling orchestrates ICM maturation and proper epiblast and primitive endoderm specification
Anna Geiselmann, Adèle Micouin, Sandrine Vandormael‐Pournin, Vincent Laville, Almira A. Chervova, Sébastien Mella, Pablo Navarro, Michel Cohen‐Tannoudji
This study identifies PI3K/AKT signaling as an upstream regulator that enables ICM formation and specifies both epiblast and primitive endoderm lineages in mouse embryos.
Developmental Cell · Oct 25, 2024Peer-reviewedDevelopmental Biology