Almira A. Chervova

MYC and MAX drive the reactivation of the genome after mitosis

This study identifies MYC and MAX as critical for post-mitotic genome reactivation in pluripotent mouse embryonic stem cells, showing MAX's role in bookmarking and MYC recruitment.

Embryonic lympho-epithelial cell interactions play an essential role in the establishment of adult T cell tolerance

This study shows that early thymic seeding progenitors are crucial for thymic epithelial maturation and regulatory T cell development, preventing age-related autoimmunity.

Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation

This study investigates how GATA6, a pioneer transcription factor, drives Primitive Endoderm differentiation by remodeling chromatin and interacting with other TFs.

Nuclear Argonaute HRDE-1 Maintains Chromatin-Independent Transcriptional Silencing through a Transgenerational Small RNA Feedback Loop

The paper shows HRDE-1 maintains transcriptional silencing in C. elegans without chromatin marks by promoting small RNA feedback loops.

Genome Architecture Shapes Transcriptional Responses to DNASupercoiling in a Multicellular Organism

This study shows DNA supercoiling affects transcription initiation and elongation in C. elegans, with directional impacts on gene expression based on genomic context.

PI3K/AKT signalling orchestrates ICM maturation and proper epiblast and primitive endoderm specification

This study identifies PI3K/AKT signaling as an upstream regulator that enables ICM formation and specifies both epiblast and primitive endoderm lineages in mouse embryos.

Nr5a2 is essential for morula development

This study shows Nr5a2 is essential for morula development in mice, as its absence causes embryonic arrest, lineage specification issues, and genome instability.

In-vitro cellular reprogramming to model gonad development and its disorders

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

Mitotic bookmarking redundancy by nuclear receptors mediates robust post-mitotic reactivation of the pluripotency network.

The paper shows that redundancy among nuclear receptor bookmarking factors ensures robust reactivation of pluripotency genes after mitosis.

H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate

The paper identifies H3K9me3 at the Nanog locus as a repressive mark that marks differentiation commitment and enables primitive endoderm fate acquisition in ES cells.

OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency

The paper identifies a genetic circuitry where OCT4 activates an antisense lncRNA that represses Suv39h1, linking H3K9 methylation levels to pluripotency in mouse ES cells.

Mitotic bookmarking by CTCF controls selected genes during the fast post-mitotic genome reactivation of ES cells

The paper shows that CTCF mitotic bookmarking enables rapid post-mitotic gene reactivation in ES cells, with some genes being sensitive to CTCF depletion.

The combined action of Esrrb and Nr5a2 is essential for naive pluripotency.

This study shows that Esrrb and Nr5a2 are essential for maintaining naive pluripotency in mouse ESCs by regulating the pluripotency network and preventing differentiation.