Sébastien Mella

NK cells undergo transcriptional and functional reprogramming following Streptococcus pneumoniae infection

This study uses single-cell RNA-seq to show that NK cells reprogram transcriptionally and functionally after Streptococcus pneumoniae infection, revealing new roles in bacterial immunity.

IL-23 tunes inflammatory functions of human mucosal-associated invariant T (MAIT) cells

This study identifies IL-23's role in shaping the functional plasticity of human MAIT cells, revealing its impact on autoimmunity and cytotoxic functions through AP-1 transcription factors.

Differential predictive value of resident memory CD8+T cell subpopulations in non-small-cell lung cancer patients treated by immunotherapy

The paper identifies two TRM subpopulations in NSCLC patients and shows that only DP TRM predicts response to PD-1 blockade immunotherapy.

PI3K/AKT signalling orchestrates ICM maturation and proper epiblast and primitive endoderm specification

This study identifies PI3K/AKT signaling as an upstream regulator that enables ICM formation and specifies both epiblast and primitive endoderm lineages in mouse embryos.

Behavioral and transcriptomic changes following brain-specific loss of noradrenergic transmission.

This study investigates the effects of brain-specific noradrenergic depletion on behavior and gene expression, finding anxiolytic effects and altered gene regulation in vulnerable brain regions.

Identification of bipotent progenitors that give rise to myogenic and connective tissues in mouse

The paper identifies Myf5+ bipotent progenitors in mice that generate both muscle and connective tissue, showing their distinct lineage and regulatory features.

SCHNAPPs - Single Cell sHiNy APPlication(s)

SCHNAPPs is a Shiny-based tool for bench-scientists to analyze scRNA-seq data, offering quality control, clustering, differential expression, and visualization with reproducible reporting.

BMP signalling directs a fibroblast-to-myoblast conversion at the connective tissue/muscle interface to pattern limb muscles

The paper identifies a fibroblast-to-myoblast conversion driven by BMP signalling at the muscle-tendon interface during limb development.