Bottom-up reconstruction of functional Death Domain Signalosomes reveals a requirement for polymer stability and avidity
Mauriz A. Lichtenstein, Fakun Cao, Finn Lobnow, Paulina Dirvanskyte, Daniel Weyhenmeyer, Anna Kulesza, Elke Ziska, Randal Halfmann, Marcus J. Taylor
The paper constructs a synthetic signalosome using Death Domains and shows that its function depends on polymer stability and avidity, demonstrating these properties are tunable and not restricted to specific motifs.
Science · Apr 24, 2025Peer-reviewedCell Biology