Marcus J. Taylor

The paper shows that LPS priming enhances TLR7-driven Myddosome assembly in macrophages, linking microbial exposure to immune adaptation and autoimmunity risk.

The paper constructs a synthetic signalosome using Death Domains and shows that its function depends on polymer stability and avidity, demonstrating these properties are tunable and not restricted to specific motifs.

This study shows IRAK4 auto-phosphorylation activates IRAK oligomerization, controlling inflammatory signaling by promoting DD domain assembly and downstream IL-1 signaling.