Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis
Johanna M. Kohlmayr, Gernot F. Grabner, Anna Nusser, Anna Katharina Holl, Verina Manojlović, Bettina Halwachs, Sarah Masser, Evelyne Jany-Luig, Hanna Engelke, Robert Zimmermann, Ulrich Stelzl
The paper identifies switch mutations in ATGL that selectively disrupt interactions with specific regulatory proteins, linking these mutations to altered lipolysis activity and disease relevance.
Nature Communications · Mar 21, 2024Peer-reviewedSystems Biology