Gernot F. Grabner

CLN8 enables a non-canonical phospholipid synthesis pathway

The paper describes a non-canonical phospholipid synthesis pathway catalyzed by CLN8, leading to BMP synthesis and revealing its role in lysosomal lipid homeostasis and Batten disease.

ATGL-mediated lipolysis is essential for myocellular mitochondrial function and augments PPARδ-induced improvements in mitochondrial respiration

The paper shows that ATGL-mediated lipolysis is essential for mitochondrial function and that PPARδ activation can improve mitochondrial respiration in myotubes with dysfunctional ATGL.

The endolysosomal phospholipid bis(monoacylglycero)phosphate is synthesized via intra- and extracellular pathways

This study identifies cytosolic and secreted transacylases that synthesize bis(monoacylglycero)phosphate (BMP) independently of CLN5, correcting BMP deficiency in CLN5-deficient cells.

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis

The paper identifies switch mutations in ATGL that selectively disrupt interactions with specific regulatory proteins, linking these mutations to altered lipolysis activity and disease relevance.