A transcriptional code controlling fluid shear stress-induced gene expression
Lucija Fleisinger, Susann Bruche, Hyewon Lim, Anna Rataj, Helena Rodriguez‐Caro, Amaury M. R. Genovese, Vinesh Vinayachandran, Svanhild Nornes, Dorota Szumska, Dhruv Gupta, Indrika Ratnayaka, Kira M. Chouliaras, Marek Giers, Simon James Conway, Alice Neal, , Sarah De Val
This paper identifies FSS-dependent enhancers for KLF2 and reveals an essential MEF2-TBP double motif in their regulation, demonstrating a specific mechanism for FSS-induced gene activation.
bioRxiv · Feb 6, 2026 · PreprintDevelopmental Biology