Svanhild Nornes

A transcriptional code controlling fluid shear stress-induced gene expression

This paper identifies FSS-dependent enhancers for KLF2 and reveals an essential MEF2-TBP double motif in their regulation, demonstrating a specific mechanism for FSS-induced gene activation.

Discovery of a primed endothelial progenitor that requires VEGF/ERK inhibition to complete vein differentiation

The paper identifies a primed endothelial progenitor that requires VEGF/ERK inhibition to differentiate into vein endothelial cells, revealing a two-step process for vein development.

Context-dependent response of endothelial cells to PIK3CA mutation

This study shows that PIK3CAH1047R mutation causes clonal expansion in capillary and venous endothelial cells but not in arterial cells, revealing stage-dependent responses and a protective mechanism against arterial damage.

A catalogue of verified and characterized arterial enhancers for key arterial identity genes.

The paper identifies and validates enhancers for key arterial genes using zebrafish and mouse models, revealing shared and distinct transcription factor binding patterns.

An autosomal dominant cardiac arrhythmia syndrome, ST Depression Syndrome, is caused by the de novo creation of a cardiomyocyte enhancer.

The paper identifies a de novo enhancer mutation in KCNB1 causing ST Depression Syndrome, a cardiac arrhythmia, and shows it can be predicted by a deep neural network.