Whole genome duplication uncouples cell volume scaling from mitochondrial homeostasis
Anna Regina Hertel, Araba Mansa Sagoe, Galal Yahya, Anna-Lena Heußer, Azkia Khan, Markus Raeschle, Johannes M. Herrmann, Zuzana Štorchová, Prince Saforo Amponsah
This study shows that polyploidy leads to reduced mitochondrial scaling and impaired metabolic function, with conserved effects across yeast and human cells.
bioRxiv · Oct 30, 2026 · PreprintCell Biology