Johannes M. Herrmann

This study shows that polyploidy leads to reduced mitochondrial scaling and impaired metabolic function, with conserved effects across yeast and human cells.

This study shows that mitochondrial presequences function in cytosolic quality control and trigger a heat shock response when mitochondrial import is inhibited.

The paper shows that succinate and its carrier Sfc1 regulate mitochondrial protein import via interaction with Tim23, affecting enzyme localization between mitochondria and cytosol.

The paper shows that mitochondrial import stress causes neurodegeneration, which is opposed by PERK-eIF2α signaling, with PERK overexpression protecting against it.

This study identifies Mrx6's role in regulating mtDNA copy number through its interaction with Pim1 and Mam33, revealing a mechanism involving substrate specificity and protein stability.

The paper identifies the cohibitin complex, including Aim11, as a quality control factor that supports TIM22-mediated insertion of carrier proteins into the mitochondrial inner membrane.

The paper shows that Zuo1, a ribosome-associated complex chaperone, mitigates growth defects and translation reduction in yeast with mitochondrial import defects under heat stress.

The paper classifies mitochondrial presequences into seven groups and identifies group A presequences as enhancing import efficiency through a specific targeting mechanism involving TOMM34.

This study shows that aneuploidy disrupts proteostasis, leading to mitochondrial dysfunction and accumulation of mitochondrial precursor proteins in cytosolic p62 bodies.

The paper shows that eukaryotic Prx1/AhpC-type peroxiredoxins form heterooligomers, which modulate their structure and stability, challenging the previous belief in homooligomerization.