Zuzana Štorchová

This study shows that polyploidy leads to reduced mitochondrial scaling and impaired metabolic function, with conserved effects across yeast and human cells.

The paper shows that Vms1 protects mitochondrial import and homeostasis during translation stress by interacting with Msp1.

The paper identifies stress-induced changes in the surfaceome, revealing osmotic stress causes surface accumulation of CI-M6PR through reduced endocytosis and increased lysosomal exocytosis.

This study shows that BLM helicase is essential for resolving ultrafine DNA bridges during mitosis, preventing genomic instability.

This study uses explainable machine learning to identify factors that buffer protein levels in aneuploid cancer cells, finding key predictors and implications for therapy.

The paper classifies mitochondrial presequences into seven groups and identifies group A presequences as enhancing import efficiency through a specific targeting mechanism involving TOMM34.

This study shows that aneuploidy disrupts proteostasis, leading to mitochondrial dysfunction and accumulation of mitochondrial precursor proteins in cytosolic p62 bodies.

The paper identifies a universal scaling law for mitotic spindles across eukaryotes, showing metaphase plate width scales with genome size following a power law with an exponent of ~1/3, driven by chromosome crowding.

The paper identifies adaptation strategies in aneuploid cancer cells through in vitro evolution and multi-omics analysis, revealing key transcription factors and genomic changes that improve proliferation and survival.

The paper investigates the effects of monosomy in human cells, finding that it impairs proliferation and genomic stability, with partial gene dosage compensation and ribosome biogenesis stress contributing to p53 pathway activation.

mitoXplorer is a web-based platform that integrates and visualizes mitochondrial gene expression and mutation data across multiple datasets to uncover regulatory differences in mitochondrial dynamics.