A Bioinformatic and Empiric Exploration of Prokaryotic Argonautes as Novel Programmable Endonuclease Systems
Šejla Šalic, Anna Sieber, Samir Barbaria, Anatoly Vasilyev, Elisavet Papadimou, Nevena Milosavljevic, Benjamin Klapholz, Rohan Sivapalan, Trevor N. Collingwood, Tom Henley, Modassir S. Choudhry, Tilmann Bürckstümmer
This study identifies and characterizes prokaryotic Argonautes (pAgos) as programmable endonucleases, showing their ability to cleave DNA in vitro with guide RNA/DNA and potential for gene editing.
bioRxiv · Mar 15, 2021 · PreprintMolecular Biology