Tom Henley

This study shows that deleting CISH enhances T cell anti-cancer functions more than other intracellular checkpoints, improving tumor antigen recognition and killing in CAR-T cells.

This study improves AAV vector genome packaging efficiency by engineering Rep hybrid proteins, reducing empty capsids and increasing full capsid yields across non-AAV2 serotypes.

This study identifies and characterizes prokaryotic Argonautes (pAgos) as programmable endonucleases, showing their ability to cleave DNA in vitro with guide RNA/DNA and potential for gene editing.