Modassir S. Choudhry

Bispecific CD20xCD40 Antibodies Achieve Multi-Lineage Modulation of Humoral and Cellular Immunity

This paper evaluates two bispecific CD20xCD40 antibodies, showing they modulate multiple immune cell types and achieve deep immunomodulation without safety issues.

CISH, a novel intracellular immune checkpoint, in comparison and combination to existing and emerging cancer immune checkpoints

This study shows that deleting CISH enhances T cell anti-cancer functions more than other intracellular checkpoints, improving tumor antigen recognition and killing in CAR-T cells.

Improved Genome Packaging Efficiency of AAV Vectors Using Rep Hybrids

This study improves AAV vector genome packaging efficiency by engineering Rep hybrid proteins, reducing empty capsids and increasing full capsid yields across non-AAV2 serotypes.

A Bioinformatic and Empiric Exploration of Prokaryotic Argonautes as Novel Programmable Endonuclease Systems

This study identifies and characterizes prokaryotic Argonautes (pAgos) as programmable endonucleases, showing their ability to cleave DNA in vitro with guide RNA/DNA and potential for gene editing.