Prpf8N1531S homozygous mutant mouse embryos have multiple defects in cardiac development and show aberrant splicing of the cardiac transcription factor Tead1
Wasay Mohiuddin Shaikh Qureshi, Haoxiang Zhou, Abigail Bennington, Nouf J. Althali, Anna van der Zwaluw, Michael Boylan, Louise A. Stephen, Kashish Jain, Basudha Basu, Dapeng Wang, Colin A. Johnson, Kathryn E. Hentges
This study identifies a critical role for Prpf8 in cardiac development through aberrant splicing of Tead1 and disrupted Notch signaling in Prpf8N1531S homozygous mutant mice.
bioRxiv · Apr 21, 2026 · PreprintDevelopmental Biology