Author

Nouf J. Althali

Manchester Academic Health Science CentreORCID 0000-0002-9141-8909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Approach:experimental assay· 1 Organism:zebrafish· 1

Frequent Co-Authors

Basudha BasuiD· 2 shared Colin A. JohnsoniD· 2 shared Dapeng WangiD· 2 shared Kathryn E. HentgesiD· 2 shared Louise A. StepheniD· 2 shared Michael Boylan· 2 shared Wasay Mohiuddin Shaikh Qureshi· 2 shared Abigail Bennington· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersDevelopmental Biology

Basudha BasuORCID

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2 papers

Recent·Most cited

Prpf8N1531S homozygous mutant mouse embryos have multiple defects in cardiac development and show aberrant splicing of the cardiac transcription factor Tead1

Wasay Mohiuddin Shaikh Qureshi, Haoxiang Zhou, Abigail Bennington, Nouf J. Althali, Anna van der Zwaluw, Michael Boylan, Louise A. Stephen, Kashish Jain, Basudha Basu, Dapeng Wang, Colin A. Johnson, Kathryn E. Hentges

This study identifies a critical role for Prpf8 in cardiac development through aberrant splicing of Tead1 and disrupted Notch signaling in Prpf8N1531S homozygous mutant mice.

bioRxiv · Apr 21, 2026 · PreprintDevelopmental Biology

The RNA splicing factor PRPF8 is required for left-right organiser cilia differentiation and determination of cardiac left-right asymmetry via regulation of Arl13b splicing

Fangfei Jiang, Michael Boylan, Dale W. Maxwell, Wasay Mohiuddin Shaikh Qureshi, Charlie F Rowlands, Gennadiy Tenin, Karen Mitchell, Louise A. Stephen, Elton J. R. Vasconcelos, Dapeng Wang, Tong Chen, Junzhe Zha, Jingshu Liu, Nouf J. Althali, Dragoș-Vasile Leordean, , Kathryn E. Hentges

This study identifies PRPF8 as essential for left-right organiser cilia function and cardiac asymmetry by regulating ARL13B splicing in mice and zebrafish.

bioRxiv · May 22, 2025 · PreprintDevelopmental Biology