Platform-Imprinted Transcriptional and Clonal Remodeling of αβ and γδT Cells After Allogeneic Transplantation
Anniek Stuut, Péter Brázda, Anke Janssen, Anna Vyborova, Froso Karaiskaki, Farid Keramati, Dorine A. De Bont, Mara J.T. Nicolasen, Lucrezia C D E Gatti, Tim J A Hutten, Jef Yildiz, H.T. Spierings, Trudy Straetemans, Dennis X. Beringer, Simona Pagliuca, , Jurgen H. E. Kuball
This study examines how different transplantation platforms affect the clonal and transcriptional changes in αβ and γδT cells over time, finding that graft engineering has a lasting impact on βTCR clonality, while viral reactivation mainly drives expansion without altering repertoire structure.
bioRxiv · Feb 10, 2026 · PreprintImmunology